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CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME
Descriptors Found:
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DeCS
Descriptor
English
:
Cholesterol Side-Chain Cleavage Enzyme
Descriptor
Spanish
:
enzima de escisión de la cadena lateral del colesterol
Descriptor
Portuguese
:
Enzima de Clivagem da Cadeia Lateral do Colesterol
Synonyms
English
:
20,22 Desmolase
20,22-Desmolase
CYP 11A1
CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cholesterol Side Chain Cleavage Enzyme
Cytochrome P 450 CYP11A1
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
Cytochrome P450 11A1
Cytochrome P450scc
Tree Number:
D08.244.453.484.250
D08.244.453.915.212
D08.811.682.690.708.170.425.250
D08.811.682.690.708.170.915.212
D12.776.422.220.453.484.250
D12.776.422.220.453.915.212
Definition
English
:
A mitochondrial
cytochrome
P450 enzyme that catalyzes the side-chain cleavage of C27
cholesterol
to C21
pregnenolone
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid
hormones.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23192
Unique Identifier:
D002786
Occurrence in VHL
:
Similar:
DeCS